TZ2
A dual GIP and incretin receptor agonist studied for incretin-pathway signaling and metabolic regulation.
01At a Glance
| Compound | TZ2 (LY3298176) |
| Classification | Metabolic research compound |
| Molecular weight | 4,813.45 g/mol |
| Sequence / Form | Synthetic 39-aa dual-incretin agonist |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
TZ2 is a synthetic 39-amino-acid peptide engineered as a dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) and incretin receptors. In research models it is studied for the combined activation of both incretin pathways and downstream effects on insulin secretion, glucose homeostasis, and energy metabolism.
Its dual-receptor mechanism is the principal distinction from single incretin agonists, making it a key reference compound in comparative incretin and metabolic-pathway research.
Research framing only · No human-use claims
03Research Context
- GIP and incretin receptor co-activation assays
- Insulin-secretion and glucose-homeostasis models
- Energy-metabolism and adipose research
- Comparative incretin-agonist studies
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is TZ2?
TZ2 is a synthetic dual GIP/incretin receptor agonist studied for incretin signaling and metabolic regulation in research models. It is sold for research use only and is not for human consumption.
How is TZ2 different from SM1?
TZ2 activates both the GIP and incretin receptors (dual agonist), while SM1 targets only the incretin receptor. The dual mechanism is the focus of comparative metabolic research.
What is the molecular weight of TZ2?
TZ2 has a molecular weight of approximately 4,813.45 g/mol and CAS number 2023788-19-2.
How should TZ2 be stored?
TZ2 ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is TZ2 approved for human use?
No. TZ2 is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is TZ2 tested at Ethos Bio?
Every TZ2 lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.