AICAR
An AMPK-activating nucleoside studied as a metabolic and exercise-mimetic tool.
01At a Glance
| Compound | AICAR |
| Also known as | Acadesine; AICA riboside |
| CAS Number | 2627-69-2 |
| Molecular Weight | 258.23 g/mol |
| Sequence / Form | Nucleoside (non-peptide) |
| Classification | Mitochondrial research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
AICAR is a nucleoside that is converted intracellularly to ZMP, an AMP mimetic that directly activates AMP-activated protein kinase (AMPK). Through AMPK it is studied for effects on glucose uptake (GLUT4 translocation), fatty-acid oxidation, and mitochondrial biogenesis (PGC-1α).
It is a classic exercise-mimetic research tool in metabolic studies. Note: AICAR is a small-molecule nucleoside, not a peptide.
03Research Applications
- 01AMPK-activation and energy-sensing assays
- 02Glucose-uptake and GLUT4 translocation models
- 03Mitochondrial-biogenesis (PGC-1α) research
- 04Exercise-mimetic metabolic studies
04Purity & Verification
Every Ethos Bio lot of AICAR is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the AICAR Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is AICAR?
AICAR is a nucleoside that activates AMPK, studied for glucose metabolism, fatty-acid oxidation, and mitochondrial biogenesis as an exercise-mimetic research tool. It is sold for research use only.
Is AICAR a peptide?
No — AICAR is a small-molecule nucleoside (AICA riboside), not a peptide, supplied as a research reagent.
What is AICAR's molecular weight?
AICAR has a molecular weight of approximately 258.23 g/mol and CAS number 2627-69-2.