GHK-Cu
A naturally occurring copper-binding tripeptide studied for gene expression and ECM remodeling.
01At a Glance
| Compound | GHK-Cu (Copper tripeptide-1) |
| Classification | Genomic research compound |
| Molecular weight | 404.92 g/mol |
| Sequence / Form | Gly-His-Lys (copper-bound) |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a sequence found in human plasma. Research attributes much of its activity to copper-ion delivery and to broad modulation of gene expression — transcriptomic studies report changes across thousands of genes, many related to extracellular-matrix (ECM) remodeling and collagen synthesis.
It is also studied for antioxidant and tissue-remodeling signaling in fibroblast and skin-model systems, strictly within research contexts.
Research framing only · No human-use claims
03Research Context
- Extracellular-matrix and collagen-synthesis studies
- Transcriptomic / gene-expression profiling
- Dermal fibroblast and skin-model research
- Copper-homeostasis and antioxidant assays
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is GHK-Cu?
GHK-Cu is a copper-binding tripeptide (glycyl-histidyl-lysine plus copper) naturally present in human plasma. It is studied for gene-expression modulation and extracellular-matrix remodeling in research models, and is sold for research use only.
Why is GHK-Cu bound to copper?
The tripeptide GHK has high affinity for copper(II) ions; the copper complex (GHK-Cu) is the form most studied in the research literature for its biochemical activity.
What is the CAS number for GHK-Cu?
GHK-Cu has CAS number 49557-75-7 and a molecular weight of approximately 404.92 g/mol.
How should GHK-Cu be stored?
GHK-Cu ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is GHK-Cu approved for human use?
No. GHK-Cu is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is GHK-Cu tested at Ethos Bio?
Every GHK-Cu lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.