GHK-Cu
A naturally occurring copper-binding tripeptide studied for gene expression and ECM remodeling.
01At a Glance
| Compound | GHK-Cu |
| Also known as | Copper tripeptide-1 |
| CAS Number | 49557-75-7 |
| Molecular Weight | 404.92 g/mol |
| Sequence / Form | Gly-His-Lys (copper-bound) |
| Classification | Genomic research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a sequence found in human plasma. Research attributes much of its activity to copper-ion delivery and to broad modulation of gene expression — transcriptomic studies report changes across thousands of genes, many related to extracellular-matrix (ECM) remodeling and collagen synthesis.
It is also studied for antioxidant and tissue-remodeling signaling in fibroblast and skin-model systems, strictly within research contexts.
03Research Applications
- 01Extracellular-matrix and collagen-synthesis studies
- 02Transcriptomic / gene-expression profiling
- 03Dermal fibroblast and skin-model research
- 04Copper-homeostasis and antioxidant assays
04Purity & Verification
Every Ethos Bio lot of GHK-Cu is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the GHK-Cu Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is GHK-Cu?
GHK-Cu is a copper-binding tripeptide (glycyl-histidyl-lysine plus copper) naturally present in human plasma. It is studied for gene-expression modulation and extracellular-matrix remodeling in research models, and is sold for research use only.
Why is GHK-Cu bound to copper?
The tripeptide GHK has high affinity for copper(II) ions; the copper complex (GHK-Cu) is the form most studied in the research literature for its biochemical activity.
What is the CAS number for GHK-Cu?
GHK-Cu has CAS number 49557-75-7 and a molecular weight of approximately 404.92 g/mol.