IGF-1 LR3
A long-acting IGF-1 analog studied for IGF-1R signaling and cell proliferation.
01At a Glance
| Compound | IGF-1 LR3 |
| Also known as | Long R3 IGF-1 |
| CAS Number | 946870-92-4 |
| Molecular Weight | 9,117.7 g/mol |
| Sequence / Form | 83-aa Long Arg3 IGF-1 analog |
| Classification | Endocrine research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
IGF-1 LR3 is an 83-amino-acid analog of insulin-like growth factor 1, modified with an Arg substitution at position 3 and an N-terminal extension that reduces binding to IGF-binding proteins, prolonging its activity in research systems.
It is studied as an agonist of the IGF-1 receptor, activating PI3K/Akt and MAPK signaling associated with cell proliferation and protein synthesis in culture models.
03Research Applications
- 01IGF-1 receptor signaling assays
- 02PI3K/Akt and MAPK pathway research
- 03Cell-proliferation and culture-supplement models
- 04Myotube hypertrophy and protein-synthesis studies
04Purity & Verification
Every Ethos Bio lot of IGF-1 LR3 is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the IGF-1 LR3 Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is IGF-1 LR3?
IGF-1 LR3 (Long R3 IGF-1) is a long-acting analog of insulin-like growth factor 1 studied for IGF-1R signaling and cell proliferation in research and cell-culture models. It is sold for research use only.
Why does IGF-1 LR3 last longer than native IGF-1?
Its structural modifications reduce binding to IGF-binding proteins, increasing free availability and prolonging activity in research systems.
What is IGF-1 LR3's molecular weight?
IGF-1 LR3 has an approximate molecular weight of 9,117.7 g/mol and CAS number 946870-92-4.