KPV
The C-terminal α-MSH tripeptide studied for NF-κB and inflammatory-signaling modulation.
01At a Glance
| Compound | KPV (α-MSH(11-13)) |
| Classification | Regenerative research compound |
| Molecular weight | 410.51 g/mol |
| Sequence / Form | Lys-Pro-Val |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone. Research focuses on its inhibition of NF-κB signaling and reduction of pro-inflammatory cytokine expression in cell models.
Notably, studies report anti-inflammatory activity that appears independent of melanocortin receptors, suggesting an intracellular mechanism — a focus of in-vitro inflammation research.
Research framing only · No human-use claims
03Research Context
- NF-κB pathway and inflammatory-signaling assays
- Pro-inflammatory cytokine-expression models
- Intestinal-epithelium and mucosal inflammation research
- Melanocortin-independent signaling studies
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is KPV?
KPV is the C-terminal tripeptide of α-MSH (Lys-Pro-Val), studied for NF-κB inhibition and anti-inflammatory signaling in research models. It is a research-use-only compound.
Does KPV act through melanocortin receptors?
Research suggests KPV's anti-inflammatory activity is largely independent of melanocortin receptors, pointing to an intracellular mechanism studied in vitro.
What is KPV's molecular weight?
KPV has a molecular weight of approximately 410.51 g/mol and CAS number 67727-97-3.
How should KPV be stored?
KPV ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is KPV approved for human use?
No. KPV is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is KPV tested at Ethos Bio?
Every KPV lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.