KPV
The C-terminal α-MSH tripeptide studied for NF-κB and inflammatory-signaling modulation.
01At a Glance
| Compound | KPV |
| Also known as | α-MSH(11-13) |
| CAS Number | 67727-97-3 |
| Molecular Weight | 410.51 g/mol |
| Sequence / Form | Lys-Pro-Val |
| Classification | Regenerative research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone. Research focuses on its inhibition of NF-κB signaling and reduction of pro-inflammatory cytokine expression in cell models.
Notably, studies report anti-inflammatory activity that appears independent of melanocortin receptors, suggesting an intracellular mechanism — a focus of in-vitro inflammation research.
03Research Applications
- 01NF-κB pathway and inflammatory-signaling assays
- 02Pro-inflammatory cytokine-expression models
- 03Intestinal-epithelium and mucosal inflammation research
- 04Melanocortin-independent signaling studies
04Purity & Verification
Every Ethos Bio lot of KPV is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the KPV Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is KPV?
KPV is the C-terminal tripeptide of α-MSH (Lys-Pro-Val), studied for NF-κB inhibition and anti-inflammatory signaling in research models. It is a research-use-only compound.
Does KPV act through melanocortin receptors?
Research suggests KPV's anti-inflammatory activity is largely independent of melanocortin receptors, pointing to an intracellular mechanism studied in vitro.
What is KPV's molecular weight?
KPV has a molecular weight of approximately 410.51 g/mol and CAS number 67727-97-3.