R3
A triple GIP / incretin / glucagon receptor agonist studied for multi-incretin metabolic signaling.
01At a Glance
| Compound | R3 (LY3437943) |
| Classification | Metabolic research compound |
| Molecular weight | 4,731.32 g/mol |
| Sequence / Form | Synthetic triple-agonist peptide |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
R3 is a synthetic triple agonist targeting the GIP, incretin, and glucagon receptors simultaneously. Research models investigate the combined contribution of all three pathways to glucose regulation, lipid metabolism, and energy expenditure.
The triple-receptor mechanism distinguishes it as a next-generation incretin research compound and a frequent subject of comparative agonist studies.
Research framing only · No human-use claims
03Research Context
- Triple incretin/glucagon receptor co-activation assays
- Glucose- and lipid-metabolism models
- Energy-expenditure and metabolic research
- Comparative multi-agonist studies
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is R3?
R3 is a synthetic triple agonist of the GIP, incretin, and glucagon receptors, studied for multi-incretin metabolic signaling in research models. It is sold for research use only.
How is R3 different from TZ2?
R3 is a triple agonist (GIP, incretin, and glucagon receptors), while TZ2 is a dual agonist (GIP and incretin). The added glucagon-receptor activity is the key research distinction.
What is R3\u2019s molecular weight?
R3 has a molecular weight of approximately 4,731.32 g/mol and CAS number 2381089-83-2.
How should R3 be stored?
R3 ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is R3 approved for human use?
No. R3 is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is R3 tested at Ethos Bio?
Every R3 lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.