Semax
A synthetic ACTH(4-10) analog studied for BDNF expression and neuroprotection.
01At a Glance
| Compound | Semax |
| Also known as | ACTH(4-7) analog |
| CAS Number | 80714-61-0 |
| Molecular Weight | 813.94 g/mol |
| Sequence / Form | Met-Glu-His-Phe-Pro-Gly-Pro |
| Classification | Cognitive research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
Semax is a synthetic heptapeptide based on the ACTH(4-10) fragment, modified for stability. Its principal research property is upregulation of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, studied in neuronal-culture and neuroprotection models.
Additional investigations examine effects on dopaminergic and serotonergic signaling and inhibition of enkephalin-degrading enzymes. All work is in research models.
03Research Applications
- 01BDNF / TrkB expression assays
- 02Neuroprotection and neuronal-survival models
- 03Dopaminergic and serotonergic signaling research
- 04Cognitive and attention behavioral models
04Purity & Verification
Every Ethos Bio lot of Semax is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the Semax Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is Semax studied for?
Semax is a synthetic ACTH(4-10) analog studied for BDNF/TrkB upregulation, neuroprotection, and monoaminergic signaling in research models. It is a research-use-only compound.
What is the sequence of Semax?
Semax has the sequence Met-Glu-His-Phe-Pro-Gly-Pro and a molecular weight of approximately 813.94 g/mol.
How does Semax differ from Selank?
Both are short research peptides studied for neuro-effects, but Semax (an ACTH analog) is most associated with BDNF and neuroprotection, while Selank (a tuftsin analog) is studied for GABAergic and anxiolytic signaling.