01At a Glance
| Compound | Semax (ACTH(4-7) analog) |
| Classification | Cognitive research compound |
| Molecular weight | 813.94 g/mol |
| Sequence / Form | Met-Glu-His-Phe-Pro-Gly-Pro |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
Semax is a synthetic heptapeptide based on the ACTH(4-10) fragment, modified for stability. Its principal research property is upregulation of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, studied in neuronal-culture and neuroprotection models.
Additional investigations examine effects on dopaminergic and serotonergic signaling and inhibition of enkephalin-degrading enzymes. All work is in research models.
Research framing only · No human-use claims
03Research Context
- BDNF / TrkB expression assays
- Neuroprotection and neuronal-survival models
- Dopaminergic and serotonergic signaling research
- Cognitive and attention behavioral models
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is Semax studied for?
Semax is a synthetic ACTH(4-10) analog studied for BDNF/TrkB upregulation, neuroprotection, and monoaminergic signaling in research models. It is a research-use-only compound.
What is the sequence of Semax?
Semax has the sequence Met-Glu-His-Phe-Pro-Gly-Pro and a molecular weight of approximately 813.94 g/mol.
How does Semax differ from Selank?
Both are short research peptides studied for neuro-effects, but Semax (an ACTH analog) is most associated with BDNF and neuroprotection, while Selank (a tuftsin analog) is studied for GABAergic and anxiolytic signaling.
How should Semax be stored?
Semax ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is Semax approved for human use?
No. Semax is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is Semax tested at Ethos Bio?
Every Semax lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.