| Attribute | Semax | Selank |
|---|---|---|
| Parent molecule | ACTH(4-10) fragment | Tuftsin analog |
| Primary research focus | BDNF / TrkB upregulation, neuroprotection | GABAergic modulation, anxiolytic signaling |
| CAS Number | 80714-61-0 | 129954-34-3 |
| Molecular Weight | 813.94 g/mol | 751.88 g/mol |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
Different parents, different pathways. Semax is based on the ACTH(4-10) fragment and is studied primarily for upregulation of BDNF and neuroprotective signaling. Selank derives from the immunopeptide tuftsin and is studied for GABAergic modulation and anxiolytic pathways.
Why they are paired. The two are frequently studied together in cognitive-decline and stress models because they address complementary neuromodulatory mechanisms — neurotrophic versus GABAergic.
View both compounds
Full mechanism, specifications, and certificates of analysis for each compound.
Frequently asked questions
What is the difference between Semax and Selank?
Semax (an ACTH(4-10) analog) is studied for BDNF/TrkB upregulation and neuroprotection, while Selank (a tuftsin analog) is studied for GABAergic and anxiolytic signaling. Both are Research Use Only neuropeptides.
Are Semax and Selank used together?
In research models they are frequently paired because they target complementary neuromodulatory pathways — neurotrophic (Semax) and GABAergic (Selank).