LL-37
The human cathelicidin antimicrobial peptide studied for membrane interaction and innate immunity.
01At a Glance
| Compound | LL-37 (Cathelicidin antimicrobial peptide; CAP-18) |
| Classification | Immune research compound |
| Molecular weight | 4,493.3 g/mol |
| Sequence / Form | 37-aa cathelicidin fragment |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
LL-37 is the only human cathelicidin-derived antimicrobial peptide, a 37-residue amphipathic α-helix. Its primary research property is interaction with and disruption of microbial membranes, the basis of its antimicrobial activity in vitro.
Beyond direct antimicrobial action, it is studied for immunomodulatory roles — chemotaxis, modulation of innate-immune signaling, and angiogenesis — in research models.
Research framing only · No human-use claims
03Research Context
- Antimicrobial membrane-disruption assays
- Amphipathic-helix / lipid-bilayer interaction research
- Innate-immune signaling and chemotaxis models
- Angiogenesis and wound-microenvironment studies
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is LL-37?
LL-37 is the human cathelicidin antimicrobial peptide, a 37-amino-acid amphipathic helix studied for membrane interaction and innate-immune signaling in research models. It is sold for research use only.
How does LL-37 interact with membranes?
LL-37 forms an amphipathic α-helix that associates with and disrupts microbial lipid membranes — the basis of the antimicrobial activity studied in vitro.
What is LL-37's molecular weight?
LL-37 has an approximate molecular weight of 4,493.3 g/mol and CAS number 154947-66-7.
How should LL-37 be stored?
LL-37 ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is LL-37 approved for human use?
No. LL-37 is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is LL-37 tested at Ethos Bio?
Every LL-37 lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.