LL-37
The human cathelicidin antimicrobial peptide studied for membrane interaction and innate immunity.
01At a Glance
| Compound | LL-37 |
| Also known as | Cathelicidin antimicrobial peptide; CAP-18 |
| CAS Number | 154947-66-7 |
| Molecular Weight | 4,493.3 g/mol |
| Sequence / Form | 37-aa cathelicidin fragment |
| Classification | Immune research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
LL-37 is the only human cathelicidin-derived antimicrobial peptide, a 37-residue amphipathic α-helix. Its primary research property is interaction with and disruption of microbial membranes, the basis of its antimicrobial activity in vitro.
Beyond direct antimicrobial action, it is studied for immunomodulatory roles — chemotaxis, modulation of innate-immune signaling, and angiogenesis — in research models.
03Research Applications
- 01Antimicrobial membrane-disruption assays
- 02Amphipathic-helix / lipid-bilayer interaction research
- 03Innate-immune signaling and chemotaxis models
- 04Angiogenesis and wound-microenvironment studies
04Purity & Verification
Every Ethos Bio lot of LL-37 is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the LL-37 Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is LL-37?
LL-37 is the human cathelicidin antimicrobial peptide, a 37-amino-acid amphipathic helix studied for membrane interaction and innate-immune signaling in research models. It is sold for research use only.
How does LL-37 interact with membranes?
LL-37 forms an amphipathic α-helix that associates with and disrupts microbial lipid membranes — the basis of the antimicrobial activity studied in vitro.
What is LL-37's molecular weight?
LL-37 has an approximate molecular weight of 4,493.3 g/mol and CAS number 154947-66-7.