MOTS-c
A mitochondrial-derived peptide studied for AMPK activation and metabolic regulation.
01At a Glance
| Compound | MOTS-c |
| Also known as | Mitochondrial ORF of the 12S rRNA type-c |
| CAS Number | 1627580-64-6 |
| Molecular Weight | 2,174.4 g/mol |
| Sequence / Form | Mitochondrial-derived 16-aa peptide |
| Classification | Mitochondrial research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
MOTS-c is a peptide encoded within the mitochondrial 12S rRNA gene. Its central research property is activation of the AMPK energy-sensing pathway, linking it to cellular metabolic homeostasis and the folate–AICAR–de novo purine biosynthesis axis.
Under metabolic stress, studies report nuclear translocation of MOTS-c where it influences stress-adaptive gene expression. It is investigated in metabolic and mitochondrial-biogenesis models only.
03Research Applications
- 01AMPK pathway and cellular energy-sensing assays
- 02Mitochondrial biogenesis and metabolic-resilience models
- 03Insulin-sensitivity and glucose-metabolism research
- 04Exercise-metabolism and metabolic-stress studies
04Purity & Verification
Every Ethos Bio lot of MOTS-c is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the MOTS-c Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA gene, studied for AMPK activation and metabolic regulation in research models. It is a research-use-only compound.
What pathway does MOTS-c activate?
In research models MOTS-c is primarily associated with activation of AMPK, a master regulator of cellular energy metabolism, and with metabolic-stress gene-expression responses.
What is MOTS-c's molecular weight?
MOTS-c has an approximate molecular weight of 2,174.4 g/mol and CAS number 1627580-64-6.