MOTS-c
A mitochondrial-derived peptide studied for AMPK activation and metabolic regulation.
01At a Glance
| Compound | MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) |
| Classification | Mitochondrial research compound |
| Molecular weight | 2,174.4 g/mol |
| Sequence / Form | Mitochondrial-derived 16-aa peptide |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
MOTS-c is a peptide encoded within the mitochondrial 12S rRNA gene. Its central research property is activation of the AMPK energy-sensing pathway, linking it to cellular metabolic homeostasis and the folate–AICAR–de novo purine biosynthesis axis.
Under metabolic stress, studies report nuclear translocation of MOTS-c where it influences stress-adaptive gene expression. It is investigated in metabolic and mitochondrial-biogenesis models only.
Research framing only · No human-use claims
03Research Context
- AMPK pathway and cellular energy-sensing assays
- Mitochondrial biogenesis and metabolic-resilience models
- Insulin-sensitivity and glucose-metabolism research
- Exercise-metabolism and metabolic-stress studies
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA gene, studied for AMPK activation and metabolic regulation in research models. It is a research-use-only compound.
What pathway does MOTS-c activate?
In research models MOTS-c is primarily associated with activation of AMPK, a master regulator of cellular energy metabolism, and with metabolic-stress gene-expression responses.
What is MOTS-c's molecular weight?
MOTS-c has an approximate molecular weight of 2,174.4 g/mol and CAS number 1627580-64-6.
How should MOTS-c be stored?
MOTS-c ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is MOTS-c approved for human use?
No. MOTS-c is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is MOTS-c tested at Ethos Bio?
Every MOTS-c lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.