Semaglutide vs R3
A side-by-side research comparison — classification, molecular weight, mechanism, and how each is verified. For laboratory research use only.
01At a Glance
| Semaglutide | R3 | |
|---|---|---|
| Classification | Metabolic | Metabolic |
| Molecular weight | 4,113.58 g/mol | 4,731.32 g/mol |
| Also known as | GLP-1 receptor agonist | LY3437943 |
| Purity spec | ≥99% HPLC | ≥99% HPLC |
| Verification | MZ Biolabs · 5-panel | MZ Biolabs · 5-panel |
| Use | Research Use Only | Research Use Only |
02How They Differ
Semaglutide
A long-acting GLP-1 receptor agonist studied for incretin signaling and glucose-metabolism research.
Semaglutide is a long-acting synthetic analog of glucagon-like peptide-1, acting as an agonist of the GLP-1 receptor. Research models study its role in incretin signaling, glucose-dependent insulin secretion, and energy-homeostasis pathways.
R3
A triple GIP / GLP-1 / glucagon receptor agonist studied for multi-incretin metabolic signaling.
R3 is a synthetic triple agonist targeting the GIP, GLP-1, and glucagon receptors simultaneously. Research models investigate the combined contribution of all three pathways to glucose regulation, lipid metabolism, and energy expenditure.
Research framing only · No human-use claims
03Selecting for a Research Model
Because Semaglutide and R3 are both metabolic research compounds, they are frequently evaluated against one another. Selection depends entirely on the research question, model system, and endpoints being measured. Both compounds are supplied strictly for in-vitro and laboratory research and are not for human or veterinary use.
Whichever you select, every Ethos Bio lot is verified the same way — a five-point independent panel with a batch-specific Certificate of Analysis. See how we test →
04FAQ
What is the difference between Semaglutide and R3?
Semaglutide is a metabolic research compound — A long-acting GLP-1 receptor agonist studied for incretin signaling and glucose-metabolism research. R3 is also studied within the metabolic area — A triple GIP / GLP-1 / glucagon receptor agonist studied for multi-incretin metabolic signaling. They differ in molecular weight (Semaglutide: 4,113.58 g/mol; R3: 4,731.32 g/mol) and primary mechanism. Both are supplied for laboratory research use only.
What are the molecular weights of Semaglutide and R3?
Semaglutide has a molecular weight of 4,113.58 g/mol. R3 has a molecular weight of 4,731.32 g/mol.
Are Semaglutide and R3 in the same research class?
Yes — both Semaglutide and R3 are categorized as Metabolic research compounds, which is why they are often compared.
How are Semaglutide and R3 tested?
Both are analyzed by an independent third-party laboratory (MZ Biolabs, Arizona) on a five-point panel — HPLC purity, mass-spectrometry identity, endotoxin, heavy metals, and sterility — with a batch-specific Certificate of Analysis provided per lot.