TB-500
A synthetic fragment of Thymosin β-4 studied for actin regulation and cell migration.
01At a Glance
| Compound | TB-500 |
| Also known as | Thymosin β-4 fragment |
| CAS Number | 77591-33-4 |
| Molecular Weight | 4,963.4 g/mol |
| Sequence / Form | Contains the LKKTETQ actin-binding motif |
| Classification | Regenerative research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
TB-500 corresponds to the active region of Thymosin β-4, a naturally occurring actin-sequestering protein. Its central LKKTETQ motif binds G-actin, and in research models it is studied for its influence on actin polymerization, cytoskeletal organization, and directed cell migration toward sites of injury.
Published investigations also examine downstream effects on angiogenesis and endothelial migration. All study contexts are in-vitro or animal-model based.
03Research Applications
- 01Actin-sequestration and cytoskeletal dynamics assays
- 02Cell-migration and chemotaxis models
- 03Angiogenesis and endothelial research
- 04Cardiac and dermal tissue-repair models
04Purity & Verification
Every Ethos Bio lot of TB-500 is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the TB-500 Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is TB-500?
TB-500 is a synthetic peptide fragment of Thymosin β-4 containing the actin-binding LKKTETQ motif. It is studied for actin regulation and cell migration in research models and is sold for research use only.
What is the difference between TB-500 and Thymosin β-4?
TB-500 represents the active actin-binding fragment of the full Thymosin β-4 protein; researchers use it as a focused tool for studying the actin-related activity attributed to the parent molecule.
What is the CAS number of TB-500?
TB-500 is associated with CAS number 77591-33-4 and an approximate molecular weight of 4,963.4 g/mol.