TB-500
A synthetic fragment of Thymosin β-4 studied for actin regulation and cell migration.
01At a Glance
| Compound | TB-500 (Thymosin β-4 fragment) |
| Classification | Regenerative research compound |
| Molecular weight | 4,963.4 g/mol |
| Sequence / Form | Contains the LKKTETQ actin-binding motif |
| Purity | ≥99% HPLC, identity verified by mass spectrometry |
| Documentation | Batch-specific Certificate of Analysis available |
| Appearance | White lyophilized powder |
| Storage | Store sealed at 2–8°C. Long-term storage per certificate guidance. |
| Use | Research Use Only. Not for human or veterinary use. |
02Mechanism of Action
TB-500 corresponds to the active region of Thymosin β-4, a naturally occurring actin-sequestering protein. Its central LKKTETQ motif binds G-actin, and in research models it is studied for its influence on actin polymerization, cytoskeletal organization, and directed cell migration toward sites of injury.
Published investigations also examine downstream effects on angiogenesis and endothelial migration. All study contexts are in-vitro or animal-model based.
Research framing only · No human-use claims
03Research Context
- Actin-sequestration and cytoskeletal dynamics assays
- Cell-migration and chemotaxis models
- Angiogenesis and endothelial research
- Cardiac and dermal tissue-repair models
04Quality & Verification
Ethos Bio presents compound information with an emphasis on identity verification, purity analysis, certificate access, and storage guidance. Product-specific documentation is available through the certificate page where applicable. Cold-chain shipping is available where required, and inventory is held under refrigerated conditions at our fulfillment center with temperature-logging protocols in place.
05FAQ
What is TB-500?
TB-500 is a synthetic peptide fragment of Thymosin β-4 containing the actin-binding LKKTETQ motif. It is studied for actin regulation and cell migration in research models and is sold for research use only.
What is the difference between TB-500 and Thymosin β-4?
TB-500 represents the active actin-binding fragment of the full Thymosin β-4 protein; researchers use it as a focused tool for studying the actin-related activity attributed to the parent molecule.
What is the CAS number of TB-500?
TB-500 is associated with CAS number 77591-33-4 and an approximate molecular weight of 4,963.4 g/mol.
How should TB-500 be stored?
TB-500 ships lyophilized and should be handled per standard research-peptide practice — kept cold, protected from light and moisture, and reconstituted only for laboratory use. Cold-chain handling is used where required. For research use only.
Is TB-500 approved for human use?
No. TB-500 is sold strictly for laboratory research use only and is not a drug or supplement. It is not approved for human or veterinary use or consumption.
How is TB-500 tested at Ethos Bio?
Every TB-500 lot is independently verified by MZ Biolabs, a third-party analytical laboratory in Arizona, on a five-point panel — RP-HPLC purity, HPLC-MS identity, endotoxin (LAL), heavy metals, and sterility. A lot-specific certificate of analysis ships with the vial. See How We Test for the full methodology.