MOTS-c vs AICAR
A side-by-side research comparison — classification, molecular weight, mechanism, and how each is verified. For laboratory research use only.
01At a Glance
| MOTS-c | AICAR | |
|---|---|---|
| Classification | Mitochondrial | Mitochondrial |
| Molecular weight | 2,174.4 g/mol | 258.23 g/mol |
| Also known as | Mitochondrial ORF of the 12S rRNA type-c | Acadesine; AICA riboside |
| Purity spec | ≥99% HPLC | ≥99% HPLC |
| Verification | MZ Biolabs · 5-panel | MZ Biolabs · 5-panel |
| Use | Research Use Only | Research Use Only |
02How They Differ
MOTS-c
A mitochondrial-derived peptide studied for AMPK activation and metabolic regulation.
MOTS-c is a peptide encoded within the mitochondrial 12S rRNA gene. Its central research property is activation of the AMPK energy-sensing pathway, linking it to cellular metabolic homeostasis and the folate–AICAR–de novo purine biosynthesis axis.
AICAR
An AMPK-activating nucleoside studied as a metabolic and exercise-mimetic tool.
AICAR is a nucleoside that is converted intracellularly to ZMP, an AMP mimetic that directly activates AMP-activated protein kinase (AMPK). Through AMPK it is studied for effects on glucose uptake (GLUT4 translocation), fatty-acid oxidation, and mitochondrial biogenesis (PGC-1α).
Research framing only · No human-use claims
03Selecting for a Research Model
Because MOTS-c and AICAR are both mitochondrial research compounds, they are frequently evaluated against one another. Selection depends entirely on the research question, model system, and endpoints being measured. Both compounds are supplied strictly for in-vitro and laboratory research and are not for human or veterinary use.
Whichever you select, every Ethos Bio lot is verified the same way — a five-point independent panel with a batch-specific Certificate of Analysis. See how we test →
04FAQ
What is the difference between MOTS-c and AICAR?
MOTS-c is a mitochondrial research compound — A mitochondrial-derived peptide studied for AMPK activation and metabolic regulation. AICAR is also studied within the mitochondrial area — An AMPK-activating nucleoside studied as a metabolic and exercise-mimetic tool. They differ in molecular weight (MOTS-c: 2,174.4 g/mol; AICAR: 258.23 g/mol) and primary mechanism. Both are supplied for laboratory research use only.
What are the molecular weights of MOTS-c and AICAR?
MOTS-c has a molecular weight of 2,174.4 g/mol. AICAR has a molecular weight of 258.23 g/mol.
Are MOTS-c and AICAR in the same research class?
Yes — both MOTS-c and AICAR are categorized as Mitochondrial research compounds, which is why they are often compared.
How are MOTS-c and AICAR tested?
Both are analyzed by an independent third-party laboratory (MZ Biolabs, Arizona) on a five-point panel — HPLC purity, mass-spectrometry identity, endotoxin, heavy metals, and sterility — with a batch-specific Certificate of Analysis provided per lot.