MOTS-c vs Glutathione
A side-by-side research comparison — classification, molecular weight, mechanism, and how each is verified. For laboratory research use only.
01At a Glance
| MOTS-c | Glutathione | |
|---|---|---|
| Classification | Mitochondrial | Mitochondrial |
| Molecular weight | 2,174.4 g/mol | 307.32 g/mol |
| Also known as | Mitochondrial ORF of the 12S rRNA type-c | GSH; reduced glutathione |
| Purity spec | ≥99% HPLC | ≥99% HPLC |
| Verification | MZ Biolabs · 5-panel | MZ Biolabs · 5-panel |
| Use | Research Use Only | Research Use Only |
02How They Differ
MOTS-c
A mitochondrial-derived peptide studied for AMPK activation and metabolic regulation.
MOTS-c is a peptide encoded within the mitochondrial 12S rRNA gene. Its central research property is activation of the AMPK energy-sensing pathway, linking it to cellular metabolic homeostasis and the folate–AICAR–de novo purine biosynthesis axis.
Glutathione
The endogenous tripeptide master antioxidant studied for redox and detoxification research.
Glutathione (GSH) is an endogenous tripeptide (γ-glutamyl-cysteinyl-glycine) and the cell's principal thiol antioxidant. Its reactive cysteine thiol neutralizes reactive oxygen species and serves as a substrate for glutathione peroxidase in redox-balance research.
Research framing only · No human-use claims
03Selecting for a Research Model
Because MOTS-c and Glutathione are both mitochondrial research compounds, they are frequently evaluated against one another. Selection depends on the research question, model system, and endpoints. Both are supplied strictly for laboratory research and are not for human or veterinary use.
Whichever you select, every Ethos Bio lot is verified the same way — a five-point independent panel with a batch-specific Certificate of Analysis. See how we test →
04FAQ
What is the difference between MOTS-c and Glutathione?
MOTS-c is a mitochondrial research compound — A mitochondrial-derived peptide studied for AMPK activation and metabolic regulation. Glutathione is also studied within the mitochondrial area — The endogenous tripeptide master antioxidant studied for redox and detoxification research. They differ in molecular weight (MOTS-c: 2,174.4 g/mol; Glutathione: 307.32 g/mol). Both are for laboratory research use only.
What are the molecular weights of MOTS-c and Glutathione?
MOTS-c: 2,174.4 g/mol. Glutathione: 307.32 g/mol.
Are MOTS-c and Glutathione in the same research class?
Yes — both are categorized as Mitochondrial research compounds.
How are MOTS-c and Glutathione tested?
Both are analyzed by an independent third-party laboratory (MZ Biolabs, Arizona) on a five-point panel — HPLC purity, mass-spec identity, endotoxin, heavy metals, and sterility — with a batch-specific Certificate of Analysis per lot.