SS-31
A mitochondria-targeted tetrapeptide studied for cardiolipin stabilization.
01At a Glance
| Compound | SS-31 |
| Also known as | Elamipretide; MTP-131 |
| CAS Number | 736992-21-5 |
| Molecular Weight | 639.79 g/mol |
| Sequence / Form | D-Arg-2,6-dimethylTyr-Lys-Phe-NH2 |
| Classification | Mitochondrial research compound |
| Appearance | Lyophilized powder |
| Purity | ≥99% (HPLC · MS-verified) |
| Storage | 2–8°C; -20°C for long-term |
| Intended Use | Research Use Only |
02Mechanism of Action
SS-31 is a cell-permeable, mitochondria-targeting tetrapeptide that concentrates on the inner mitochondrial membrane, where it selectively binds the phospholipid cardiolipin. Research models report that this interaction stabilizes cristae architecture and supports efficient electron transport.
By preserving membrane organization it is studied for its capacity to reduce reactive-oxygen-species (ROS) generation and protect mitochondrial bioenergetics.
03Research Applications
- 01Cardiolipin-binding and inner-membrane assays
- 02Mitochondrial bioenergetics and cristae-architecture research
- 03Reactive-oxygen-species (ROS) reduction models
- 04Cardiac and neuronal mitochondrial-stress studies
04Purity & Verification
Every Ethos Bio lot of SS-31 is analyzed by reverse-phase HPLC and independently confirmed by mass spectrometry through our third-party testing partner, Janoshik Analytical. A signed Certificate of Analysis documenting identity and ≥99% purity is provided for every lot.
View the SS-31 Certificate of Analysis
Independent third-party HPLC & mass-spec verification. The COA shipped with your order reflects your specific lot.
05Frequently Asked Questions
What is SS-31?
SS-31 (elamipretide) is a mitochondria-targeted tetrapeptide studied for binding cardiolipin on the inner mitochondrial membrane, stabilizing cristae and reducing ROS in research models. It is sold for research use only.
What does SS-31 bind to?
SS-31 selectively binds cardiolipin, a phospholipid of the inner mitochondrial membrane central to electron-transport-chain organization.
What is SS-31's molecular weight?
SS-31 has a molecular weight of approximately 639.79 g/mol and CAS number 736992-21-5.