TB-500 vs ARA-290
A side-by-side research comparison — classification, molecular weight, mechanism, and how each is verified. For laboratory research use only.
01At a Glance
| TB-500 | ARA-290 | |
|---|---|---|
| Classification | Regenerative | Regenerative |
| Molecular weight | 4,963.4 g/mol | 1,258.42 g/mol |
| Also known as | Thymosin β-4 fragment | Cibinetide |
| Purity spec | ≥99% HPLC | ≥99% HPLC |
| Verification | MZ Biolabs · 5-panel | MZ Biolabs · 5-panel |
| Use | Research Use Only | Research Use Only |
02How They Differ
TB-500
A synthetic fragment of Thymosin β-4 studied for actin regulation and cell migration.
TB-500 corresponds to the active region of Thymosin β-4, a naturally occurring actin-sequestering protein. Its central LKKTETQ motif binds G-actin, and in research models it is studied for its influence on actin polymerization, cytoskeletal organization, and directed cell migration toward sites of injury.
ARA-290
An erythropoietin-derived peptide studied for innate-repair-receptor signaling.
ARA-290 (cibinetide) is an 11-amino-acid peptide derived from the helix-B region of erythropoietin. It is studied as a selective agonist of the innate repair receptor — a heterocomplex of the EPO receptor and the β-common receptor (CD131) — associated with tissue protection and anti-inflammatory signaling.
Research framing only · No human-use claims
03Selecting for a Research Model
Because TB-500 and ARA-290 are both regenerative research compounds, they are frequently evaluated against one another. Selection depends on the research question, model system, and endpoints. Both are supplied strictly for laboratory research and are not for human or veterinary use.
Whichever you select, every Ethos Bio lot is verified the same way — a five-point independent panel with a batch-specific Certificate of Analysis. See how we test →
04FAQ
What is the difference between TB-500 and ARA-290?
TB-500 is a regenerative research compound — A synthetic fragment of Thymosin β-4 studied for actin regulation and cell migration. ARA-290 is also studied within the regenerative area — An erythropoietin-derived peptide studied for innate-repair-receptor signaling. They differ in molecular weight (TB-500: 4,963.4 g/mol; ARA-290: 1,258.42 g/mol). Both are for laboratory research use only.
What are the molecular weights of TB-500 and ARA-290?
TB-500: 4,963.4 g/mol. ARA-290: 1,258.42 g/mol.
Are TB-500 and ARA-290 in the same research class?
Yes — both are categorized as Regenerative research compounds.
How are TB-500 and ARA-290 tested?
Both are analyzed by an independent third-party laboratory (MZ Biolabs, Arizona) on a five-point panel — HPLC purity, mass-spec identity, endotoxin, heavy metals, and sterility — with a batch-specific Certificate of Analysis per lot.