Thymosin Alpha-1 vs LL-37
A side-by-side research comparison — classification, molecular weight, mechanism, and how each is verified. For laboratory research use only.
01At a Glance
| Thymosin Alpha-1 | LL-37 | |
|---|---|---|
| Classification | Immune | Immune |
| Molecular weight | 3,108.3 g/mol | 4,493.3 g/mol |
| Also known as | Tα1; Thymalfasin | Cathelicidin antimicrobial peptide; CAP-18 |
| Purity spec | ≥99% HPLC | ≥99% HPLC |
| Verification | MZ Biolabs · 5-panel | MZ Biolabs · 5-panel |
| Use | Research Use Only | Research Use Only |
02How They Differ
Thymosin Alpha-1
A thymic peptide studied for T-cell maturation and Toll-like-receptor signaling.
Thymosin Alpha-1 is a 28-amino-acid N-terminally acetylated peptide derived from the thymic protein prothymosin alpha. Research focuses on its role in T-cell maturation and differentiation and modulation of Toll-like receptors (TLR2, TLR9) on dendritic cells.
LL-37
The human cathelicidin antimicrobial peptide studied for membrane interaction and innate immunity.
LL-37 is the only human cathelicidin-derived antimicrobial peptide, a 37-residue amphipathic α-helix. Its primary research property is interaction with and disruption of microbial membranes, the basis of its antimicrobial activity in vitro.
Research framing only · No human-use claims
03Selecting for a Research Model
Because Thymosin Alpha-1 and LL-37 are both immune research compounds, they are frequently evaluated against one another. Selection depends entirely on the research question, model system, and endpoints being measured. Both compounds are supplied strictly for in-vitro and laboratory research and are not for human or veterinary use.
Whichever you select, every Ethos Bio lot is verified the same way — a five-point independent panel with a batch-specific Certificate of Analysis. See how we test →
04FAQ
What is the difference between Thymosin Alpha-1 and LL-37?
Thymosin Alpha-1 is a immune research compound — A thymic peptide studied for T-cell maturation and Toll-like-receptor signaling. LL-37 is also studied within the immune area — The human cathelicidin antimicrobial peptide studied for membrane interaction and innate immunity. They differ in molecular weight (Thymosin Alpha-1: 3,108.3 g/mol; LL-37: 4,493.3 g/mol) and primary mechanism. Both are supplied for laboratory research use only.
What are the molecular weights of Thymosin Alpha-1 and LL-37?
Thymosin Alpha-1 has a molecular weight of 3,108.3 g/mol. LL-37 has a molecular weight of 4,493.3 g/mol.
Are Thymosin Alpha-1 and LL-37 in the same research class?
Yes — both Thymosin Alpha-1 and LL-37 are categorized as Immune research compounds, which is why they are often compared.
How are Thymosin Alpha-1 and LL-37 tested?
Both are analyzed by an independent third-party laboratory (MZ Biolabs, Arizona) on a five-point panel — HPLC purity, mass-spectrometry identity, endotoxin, heavy metals, and sterility — with a batch-specific Certificate of Analysis provided per lot.